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Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

Pharmacology D. Pharma B. Pharma Bachelor of Pharmacy Diploma in Pharmacy

Q. 5 of Quiz-872 (Que-ID : 1489)

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

  • Undergoes little first-pass metabolism
  • Is incompletely absorbed
  • Is freely water soluble
  • Is completely absorbed

Ans → (b)Is incompletely absorbed

Explanation →

This question is taken from this post → Pharmacology MCQs | Quiz on General Pharmacological Principles - attemp/practice


More MCQs in - Pharmacology MCQs | Quiz on General Pharmacological Principles

Q. 1 of Quiz-872 (Que-ID : 1485)

Compared to subcutaneous injection, the intramus- cular injection of drugs:

  • Is more painful
  • Produces faster response
  • Is unsuitable for depot preparations
  • Carries greater risk of anaphylactic reaction

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Q. 2 of Quiz-872 (Que-ID : 1486)

The majority of drugs cross biological membranes primarily by

  • Passive diffusion
  • Facilitated diffusion
  • Active transport
  • Pinocytosis

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Q. 3 of Quiz-872 (Que-ID : 1487)

Which of the following drugs is most likely to be absorbed from the stomach

  • Hyoscine hydrobromide
  • Morphine sulfate
  • Diclofenac sodium
  • Quinine dihydrochloride

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Q. 4 of Quiz-872 (Que-ID : 1488)

The most important factor governing absorption of a drug from intact skin is

  • Nature of the base used in the formulation
  • Lipid solubility of the drug
  • Molecular weight of the drug
  • Site of application

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Q. 5 of Quiz-872 (Que-ID : 1489)

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

  • Undergoes little first-pass metabolism
  • Is incompletely absorbed
  • Is freely water soluble
  • Is completely absorbed

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Q. 6 of Quiz-872 (Que-ID : 1490)

Marked redistribution is a feature of

  • Highly plasma protein bound drugs
  • Depot preparations
  • Highly lipid soluble drugs
  • Poorly lipid soluble drugs

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Q. 7 of Quiz-872 (Que-ID : 1491)

High plasma protein binding

  • Increases volume of distribution of the drug
  • Generally makes the drug long acting
  • Facilitates glomerular filtration of the drug
  • Minimises drug interactions

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Q. 8 of Quiz-872 (Que-ID : 1492)

Which of the following is a prodrug

  • Enalapril
  • Menapril
  • Thiazine
  • Penicillin

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Q. 9 of Quiz-872 (Que-ID : 1493)

Microsomal enzyme induction can be a cause of

  • Tolerance
  • Physical dependence
  • Psychological dependence
  • Idiosyncrasy

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Q. 10 of Quiz-872 (Que-ID : 1494)

Glomerular filtration of a drug is affected by its

  • Plasma protein binding
  • Lipid solubility
  • Degree of ionization
  • Rate of tubular secretion

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Directions : For each question, choose a correct option from given four options (A, B, C and D)

Q. 5 of Quiz- (Que-ID : 1219)

which one of these is used to increase the serum level of penicilline?

  • Aspirin
  • Ranitidine
  • Probenecid
  • Aluminium hydroxide gel

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Q. 23 of Quiz- (Que-ID : 1089)

Vermox is a common brand for -

  • Thiabendazole
  • Piperazine
  • Mebendazole
  • Metronidazole

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Q. 4 of Quiz- (Que-ID : 1384)

Quinine and quinidine is differ in-

  • Chemical structure
  • solubility
  • In rotating the plane of polarized light
  • none of the above

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Q. 10 of Quiz- (Que-ID : 1390)

Nux-vomica seed belongs to the family-

  • Rubiaceae
  • Loganiaceae
  • Papaveraceae
  • Apocynaceae

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Q. 19 of Quiz- (Que-ID : 1202)

The Imprest system is used in relation to -

  • Sales book
  • Purchase book
  • Petty cash book
  • Journal

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Q. 16 of Quiz- (Que-ID : 103)

Which of the following metabolite of cyclophosphamide is responsible for its anti-tumor actitivity?

  • Phosphoramide mustard
  • Acrolein
  • Aldophosphamide
  • 4-hydroxy cyclophosphamide

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Q. 6 of Quiz- (Que-ID : 16)

Which one of these is non barbiturate, used for paediatric anaesthesia?

  • Nikethamide
  • Morphine
  • Ketamine
  • None of these

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Q. 33 of Quiz- (Que-ID : 120)

Tragacanth in water is associated with

  • Plastic flow
  • Pseudoplatic flow
  • Dialatant flow
  • None of these

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Q. 2 of Quiz- (Que-ID : 1811)

Which of these hypnotic possess a muscle relaxant property?

  • Paraldehyde
  • Phenobarbitone
  • Barbitone
  • Diazepam

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Q. 12 of Quiz- (Que-ID : 685)

In which dryer, drying takes place at very low temprature?

  • Sublimation dryer
  • Vacuum dryer
  • Fluidized bed dryer
  • Rotatory dryer

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Q. 13 of Quiz- (Que-ID : 630)

Schedule F2 of Drug and Cosmetic act is related to - 

  • Standards for opthalmic preparations
  • Standards for surgical dressings
  • Standards for sterilized umbilical tapes
  • Standards for disinfectant fluids

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Q. 17 of Quiz- (Que-ID : 1695)

Tincture of iodine is -

  • Strong iodine solution
  • weak iodine solution
  • Aqueous iodine solution
  • none of the above

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Q. 8 of Quiz- (Que-ID : 1358)

Microcytic hypochromic anemia occurs due to deficiency of-

  • Cu++
  • CO2
  • Zinc
  • Iron

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Q. 10 of Quiz- (Que-ID : 1466)

The partner having authority to check the books of account for information besides not a part of Managing firm is…

  • General partners
  • Limited partner
  • Special partners
  • All of them

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Q. 12 of Quiz- (Que-ID : 1321)

Partners who are neither entitled to take part in the management nor do they invest and get a share of profits are-

  • silent partners
  • Prtners by estoppel
  • Nominal partner
  • Limited partner

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Q. 5 of Quiz- (Que-ID : 1677)

_______ is expressed in both the intestinal epithelium and the kidney.

  • CYP378A
  • CYP4B2
  • CYP3A4
  • CYP256

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Q. 13 of Quiz- (Que-ID : 1079)

Quinidine acts as antiarrhythmic drug by -

  • Calcium channel blockade
  • β -receptor blockade
  • Sodium channel blockade
  • None of the above

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Q. 26 of Quiz- (Que-ID : 1092)

Which one of these vitamin is a naphthaquinone derivative?

  • Vitamin C
  • Vitamin A
  • Vitamin K
  • Vitamin D

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Q. 4 of Quiz- (Que-ID : 1488)

The most important factor governing absorption of a drug from intact skin is

  • Nature of the base used in the formulation
  • Lipid solubility of the drug
  • Molecular weight of the drug
  • Site of application

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Directions : For each question, choose a correct option from given four options (A, B, C and D)

Q. 24 of Quiz- (Que-ID : 1238)

The overbed trapeze bar is used for-

  • Hanging 1/v solution /drip
  • repositioning the patient while sleeping
  • safety rail on a hospital bed
  • sitting up and getting into and out of bed by the patient

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Q. 23 of Quiz- (Que-ID : 1116)

Which one of these sulpha drug possess guanidine, used in bacillary dysentery?

  • Sulphadiazine
  • Sulphadimidine
  • Sulphaguanidine
  • Sulphasomidine

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Q. 3 of Quiz- (Que-ID : 1186)

In VED analysis D stands for-

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  • Deviation of stock
  • Daily desired item

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Q. 23 of Quiz- (Que-ID : 2235)

Oxygen is used in the treatment of-

  • CO poisoning
  • Lead poisoning
  • Mercury poisoning
  • Blood pressure

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Q. 24 of Quiz- (Que-ID : 1117)

The basic ring present in estradiol (female sex hormone) -

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  • 5 α - pregnane
  • None of the above

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Q. 28 of Quiz- (Que-ID : 115)

Removal of para-nitro group of chloramphenicol may

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  • Decreases bitterness
  • Decreses potency
  • Increases water solubility

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Q. 2 of Quiz- (Que-ID : 1519)

Which one of the following traits is not a characteristic of life shared by all organisms?

  • growth
  • circulation
  • photosynthesis
  • digestion

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Q. 18 of Quiz- (Que-ID : 1111)

The muscle relaxant 'meprobamate' is a derivative of -

  • Dicarbamate
  • Dioic acid
  • Diamine
  • Diol

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Q. 19 of Quiz- (Que-ID : 1369)

In TCA, oxaloacetate is formed from-

  • Fumarate
  • L-ketoglutarate
  • succinate
  • Malate

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Q. 10 of Quiz- (Que-ID : 3860)

Increase in number of erythrocytes

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  • Reticulocytes
  • displacia
  • Polycythemia

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Q. 2 of Quiz- (Que-ID : 1569)

In which of the following bone structures do osteocytes live?

  • canaliculi
  • osteons
  • lacunae
  • lamellae

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Q. 9 of Quiz- (Que-ID : 1586)

An oxidative pathway of glucose-6-phosphate is also known as…

  • Phosphogluconate pathway
  • Pentose phosphate pathway
  • Hexose monophosphate pathway
  • All of them

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Q. 15 of Quiz- (Que-ID : 1844)

Which of the following is the carbohydrate of animal origin?

  • Glucose
  • Sucrose
  • starch
  • Glycogen

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Q. 2 of Quiz- (Que-ID : 1352)

The major site of fat digestion is-

  • Large intestine
  • small intestine
  • Kidney
  • Liver

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Q. 6 of Quiz- (Que-ID : 1684)

The colour of the cylinder of nitrous oxide is-

  • Red
  • Blue
  • Black
  • Orange

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Q. 12 of Quiz- (Que-ID : 463)

The citrate is converted into isocitrate via cis-aconitase by the enzyme:

  • Cutrate synthase
  • aconitase
  • isocitrate dehydrogenate
  • malate dehydrogenase

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Q. 1 of Quiz- (Que-ID : 411)

Suganril is common brand name for:

  • Phenylbutazone
  • Piroxican
  • Benorylate
  • Indomethacin

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Q. 1 of Quiz- (Que-ID : 3851)

The glycolytic pathway is the

  • Conversion of pyruvic acid into oxaloacetate
  • Degradation of glucose into pyruvic acid
  • Successive oxidation - reduction reaction involving succinate NADH
  • None of these

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Q. 16 of Quiz- (Que-ID : 1169)

Dextrose injection is sterilised by

  • Hot air oven
  • Autoclave
  • Tyndallization
  • Pasteurization

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Q. 6 of Quiz- (Que-ID : 1513)

Select the drug which is administered orally for erectile dysfunction in men

  • Albendazole
  • Mebendazole
  • Cocaine
  • Sildenafil

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Q. 15 of Quiz- (Que-ID : 1365)

Intracellular substance present in connective tissue is-

  • Fatty in nature
  • Muco polysaccharide
  • Protein
  • none of the above

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Q. 11 of Quiz- (Que-ID : 1194)

Induction training is meant for -

  • Existing employees
  • New employees
  • Both (a) and (b)
  • None of the above

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Q. 9 of Quiz- (Que-ID : 1516)

The drug which produces vasoconstriction despite being an α adrenergic blocker is

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  • Desmopressin
  • Ergotamine
  • Sildenafil

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